Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Anaplastic thyroid cancer
ADR ID BADD_A00216
ADR Hierarchy
16      Neoplasms benign, malignant and unspecified (incl cysts and polyps)
16.24      Endocrine neoplasms malignant and unspecified
16.24.03      Thyroid neoplasms malignant
16.24.03.003      Anaplastic thyroid cancer
05      Endocrine disorders
05.02      Thyroid gland disorders
05.02.05      Thyroid neoplasms
05.02.05.006      Anaplastic thyroid cancer
Description An aggressive THYROID GLAND malignancy which generally occurs in IODINE-deficient areas in people with previous thyroid pathology such as GOITER. It is associated with CELL DEDIFFERENTIATION of THYROID CARCINOMA (e.g., FOLLICULAR THYROID CARCINOMA; PAPILLARY THYROID CANCER). Typical initial presentation is a rapidly growing neck mass which upon metastasis is associated with DYSPHAGIA; NECK PAIN; bone pain; DYSPNEA; and NEUROLOGIC DEFICITS. [MeSH]
MedDRA Code 10002240
MeSH ID D065646
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Anaplastic thyroid cancer | Thyroid Carcinoma, Anaplastic | Anaplastic Thyroid Carcinoma | Anaplastic Thyroid Carcinomas | Carcinoma, Anaplastic Thyroid | Carcinomas, Anaplastic Thyroid | Thyroid Carcinomas, Anaplastic | Thyroid Cancer, Anaplastic | Anaplastic Thyroid Cancer | Anaplastic Thyroid Cancers | Cancer, Anaplastic Thyroid | Cancers, Anaplastic Thyroid | Thyroid Cancers, Anaplastic
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00566Dabrafenib0.000168%
BADD_D01966Ropinirole--
BADD_D02058Sorafenib0.000112%
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