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Drug-Induced Toxicity Related Proteins

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Drug-induced toxicity related proteins (DITRPs) are proteins that mediate toxicities through their interaction with drugs or reactive metabolites.Collection of these proteins will in large extent facilitates better understanding of the molecular mechanisms of drug-induced toxicity and the rational drug discovery.

Drug-Induced Toxicity Related Protein Database (DITOP) is a comprehensive database that provides DITRPs-related information. Currently, DITOP contains 618 distinct literature-reported DITRPs, 529 drugs/ligands, and 418 distinct toxicity terms. The related toxicities include overdose toxicity, idosycratic toxicity, drug-drug interactions and genetic toxicity. (statistics)

To cite: Zhang JX, Huang WJ, Zeng JH, Huang WH, Wang Y, Zhao R, Han BC, Liu QF, Chen YZ, Ji ZL. DITOP: drug-induced toxicity related protein database. Bioinformatics. 2007 Jul 1;23(13):1710-2. (Pubmed ID: 17463030)

Related Resources

ADMEAP-Drug ADME Associated Protein Database. A database for facilitating the search for drug Absorption, Distribution, Metabolism, Excretion associated proteins.

EDGE -Environment, Drugs and Gene Expression. A scientific resource for toxicology-related gene expression information.

CEBS -Chemical Effects in Biological Systems (CEBS)

NCTR -National Center For Toxicological Research

DSSTox -Distributed Structure-Searchable Toxicity (DSSTox) Database Network .

UM-BBD Pathway Prediction System -A system predicts microbial catabolic reactions using substructure searching, a rule-base, and atom-to-atom mapping.

TOXNET -Databases on toxicology, hazardous chemicals, environmental health, and toxic releases.

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