Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tetracosactide
Drug ID BADD_D02178
Description Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. Tetracosactide exhibits the same activity as natural ACTH with regard to all its biological activities. The complex results in a product whose absorption in man is effected over a longer period of time as compared to corticotropin. Therefore, therapy may be maintained with less frequent administration.
Indications and Usage For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.
Marketing Status approved
ATC Code H01AA02
DrugBank ID DB01284
KEGG ID D00284
MeSH ID D003366
PubChem ID 16133802
TTD Drug ID D0W6LI
NDC Product Code 55463-0015
UNII 72YY86EA29
Synonyms Cosyntropin | ACTH 1-24 | Corticotropin (1-24)-Peptide | Corticotropin (1-24)-Tetracosapeptide | ACTH (1-24) | Tetracosactide | Tetracosactrin | Tetracosapeptide | 1-24-Corticotropin | 1-24-ACTH | Synthetic ACTH | ACTH, Synthetic | Cortrosyn | Cortosyn
Chemical Information
Molecular Formula C136H210N40O31S
CAS Registry Number 16960-16-0
SMILES CC(C)C(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N) C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=C(C=C2)O)C( =O)N3CCCC3C(=O)O)NC(=O)C4CCCN4C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC5=CNC6=CC=CC=C65)NC( =O)C(CCCNC(=N)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(CC8=CNC=N8)NC(=O)C(CCC(=O)O)NC(=O)C (CCSC)NC(=O)C(CO)NC(=O)C(CC9=CC=C(C=C9)O)NC(=O)C(CO)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic shock10.01.07.002; 24.06.02.004---
Bradycardia02.03.02.002---
Dermatitis23.03.04.002---
Erythema23.03.06.001---
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Rash23.03.13.001---
Tachycardia02.03.02.007---
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