Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Marketing Status approved
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
UNII X1J18R4W8P
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Jaw fistula07.11.05.021; 15.02.04.0450.000066%-
Joint noise15.01.02.0120.000264%-
Laryngeal ulceration22.04.01.0140.000044%-
Lip neoplasm07.21.08.003; 16.13.09.0030.000044%-
Lipoma of breast16.14.01.008; 21.05.01.0310.000066%-
Loose body in joint15.01.02.0130.000088%-
Mandibular mass08.03.05.011; 15.03.05.0210.000044%-
Medical device pain08.07.01.0160.000220%-
Myofascial spasm15.05.03.039; 17.05.03.0200.000044%-
Myxoid cyst15.04.02.006; 23.03.03.0930.000044%-
Oesophageal hypomotility07.02.02.021---
Oral fibroma07.20.02.005; 16.05.04.0040.000044%-
Osteochondritis15.07.03.0090.000044%-
Osteoporosis postmenopausal14.04.04.019; 15.02.03.020; 21.02.02.0060.000044%-
Ovarian calcification21.11.02.0210.000044%-
Pelvic organ prolapse21.07.04.0160.000044%-
Pharyngeal swelling22.04.05.028---
Pinguecula06.06.02.0130.000044%-
Pulmonary hilum mass22.09.03.0150.000044%-
Pulpless tooth07.09.12.0020.000154%-
Salivary gland adenoma07.20.02.007; 16.05.04.0060.000044%-
Senile osteoporosis14.04.04.021; 15.02.03.0220.000066%-
Spinal claudication17.10.01.030; 24.04.06.0500.000044%-
Spinal meningeal cyst16.09.05.006; 17.18.05.0060.000044%-
Spinal stenosis15.10.04.014; 17.10.01.0310.001343%-
Surgical failure08.06.01.0490.000088%-
Tongue neoplasm benign07.20.02.008; 16.05.04.0070.000044%-
Traumatic occlusion07.09.05.0190.000044%-
Tympanosclerosis04.05.04.0040.000044%-
Uterine cervix atrophy21.06.01.0200.000044%-
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