Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Abacavir
Drug ID BADD_D00008
Description Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free base, abacavir.
Indications and Usage For the treatment of HIV-1 infection, in combination with other antiretroviral agents.
Marketing Status Prescription
ATC Code J05AF06
DrugBank ID DB01048
KEGG ID D07057
MeSH ID C106538
PubChem ID 441300
TTD Drug ID D0A4IJ
NDC Product Code 50268-049; 55111-920; 65862-073; 0121-0897; 72865-167; 0904-6874; 70518-1274; 31722-562; 31722-557; 69097-514; 64380-717
Synonyms abacavir | 1592U89 | abacavir sulfate | Ziagen | (1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopentene-1-methanol | abacavir succinate
Chemical Information
Molecular Formula C14H18N6O
CAS Registry Number 136470-78-5
SMILES C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.028334%Not Available
Abdominal pain07.01.05.0020.028334%
Abnormal dreams17.15.02.001; 19.02.03.001--Not Available
Abortion spontaneous18.01.04.0010.047224%Not Available
Acute myocardial infarction02.02.02.001; 24.04.04.0010.018890%Not Available
Acute respiratory distress syndrome22.01.03.001--
Alanine aminotransferase increased13.03.01.003--
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Anxiety19.06.02.002--
Aplasia pure red cell01.03.03.001; 10.02.01.003--Not Available
Aplastic anaemia01.03.03.002--Not Available
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.0010.018890%Not Available
Basedow's disease05.02.02.003; 06.09.04.003; 10.04.08.004--Not Available
Blood bilirubin increased13.03.01.008--
Blood creatine phosphokinase increased13.04.01.001--
Blood creatinine increased13.13.01.004--
Blood triglycerides increased13.12.03.0010.018890%Not Available
Body temperature increased13.15.01.001--Not Available
Breast cancer16.10.01.001; 21.05.01.0030.037779%Not Available
Breast enlargement21.05.04.001--Not Available
Bronchitis11.01.09.001; 22.07.01.001--
Cerebrovascular accident17.08.01.007; 24.03.05.0010.018890%
Chills08.01.09.001; 15.05.03.0160.018890%
Conjunctivitis06.04.01.002; 11.01.06.012--
Cough22.02.03.0010.037779%
Death08.04.01.0010.022175%
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ADReCS-Target
Drug Name ADR Term Target
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