Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Oesophageal squamous cell carcinoma
ADR ID BADD_A08563
ADR Hierarchy
07      Gastrointestinal disorders
07.21      Malignant and unspecified neoplasms gastrointestinal NEC
07.21.06      Oesophageal neoplasms malignant
07.21.06.004      Oesophageal squamous cell carcinoma
16      Neoplasms benign, malignant and unspecified (incl cysts and polyps)
16.13      Gastrointestinal neoplasms malignant and unspecified
16.13.06      Oesophageal neoplasms malignant
16.13.06.004      Oesophageal squamous cell carcinoma
Description A carcinoma that originates usually from cells on the surface of the middle and lower third of the ESOPHAGUS. Tumor cells exhibit typical squamous morphology and form large POLYPLOID lesions. Mutations in RNF6, LZTS1, TGFBR2, DEC1, and WWOX1 genes are associated with this cancer. [MeSH]
MedDRA Code 10061534
MeSH ID D000077277
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Esophageal epidermoid carcinoma NOS | Esophageal squamous cell carcinoma abdominal stage unspecified | Esophageal squamous cell carcinoma cervical stage unspecified | Esophageal squamous cell carcinoma lower third stage unspecified | Esophageal squamous cell carcinoma middle third stage unspecified | Esophageal squamous cell carcinoma stage unspecified | Esophageal squamous cell carcinoma thoracic stage unspecified | Esophageal squamous cell carcinoma upper third stage unspecified | Oesophageal epidermoid carcinoma NOS | Oesophageal squamous cell carcinoma NOS | Squamous cell carcinoma of esophagus | Squamous cell carcinoma of esophagus NOS | Esophageal squamous cell carcinoma | Oesophageal squamous cell carcinoma abdominal stage unspecified | Oesophageal squamous cell carcinoma cervical stage unspecified | Oesophageal squamous cell carcinoma lower third stage unspecified | Oesophageal squamous cell carcinoma middle third stage unspecified | Oesophageal squamous cell carcinoma stage unspecified | Oesophageal squamous cell carcinoma thoracic stage unspecified | Oesophageal squamous cell carcinoma upper third stage unspecified | Squamous cell carcinoma of oesophagus | Oesophageal squamous cell carcinoma | Basal cell carcinoma of oesophagus | Basal cell carcinoma of esophagus | Oesophageal squamous cell carcinoma non-resectable | Esophageal squamous cell carcinoma non-resectable | Esophageal Squamous Cell Carcinoma
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00066Alendronic acid0.000044%
BADD_D01253Lenalidomide0.000241%
BADD_D02105Tacrolimus0.000297%
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