Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Constipation
ADR ID BADD_A01059
ADR Hierarchy
07      Gastrointestinal disorders
07.02      Gastrointestinal motility and defaecation conditions
07.02.02      Gastrointestinal atonic and hypomotility disorders NEC
07.02.02.001      Constipation
Description A disorder characterized by irregular and infrequent or difficult evacuation of the bowels. [CTCAE] Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections. | Difficult defecation. | Symptom characterized by the passage of stool once a week or less. [MeSH]
MedDRA Code 10010774
MeSH ID D003248
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Constipation | Constipation (excl faecal impaction) | Iatrogenic constipation | Obstipation | Constipation aggravated | Constipation (excl fecal impaction) | Stools absent | Constipation chronic | Opioid induced constipation | Slow transit constipation | Chronic idiopathic constipation | Absent bowel movement | Habitual constipation | Dyschezia | Colonic Inertia
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02037Sodium cation--
BADD_D02048Sodium phenylbutyrate--
BADD_D02049Sodium polystyrene sulfonate--
BADD_D02053Sofosbuvir0.011798%
BADD_D02054Solifenacin succinate--
BADD_D02055Somatropin--
BADD_D02056Somatuline depot--
BADD_D02058Sorafenib0.006022%
BADD_D02062Sparfloxacin--
BADD_D02068Stavudine--
BADD_D02076Strontium ranelate--
BADD_D02077Styrenesulfonic acid--
BADD_D02081Sucralfate--
BADD_D02085Sugammadex sodium--
BADD_D02097Sulindac--
BADD_D02098Sumatriptan--
BADD_D02099Sumatriptan succinate--
BADD_D02100Sunitinib0.013387%
BADD_D02101Sunitinib malate--
BADD_D02104Tacrine hydrochloride--
BADD_D02105Tacrolimus--
BADD_D02106Tadalafil--
BADD_D02107Tafamidis0.009959%
BADD_D02111Tamoxifen0.000523%
BADD_D02112Tamoxifen citrate--
BADD_D02113Tamsulosin0.000134%
BADD_D02114Tamsulosin hydrochloride--
BADD_D02115Tapentadol0.010066%
BADD_D02116Tapentadol hydrochloride--
BADD_D02118Tasimelteon0.002064%
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