Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Constipation
ADR ID BADD_A01059
ADR Hierarchy
07      Gastrointestinal disorders
07.02      Gastrointestinal motility and defaecation conditions
07.02.02      Gastrointestinal atonic and hypomotility disorders NEC
07.02.02.001      Constipation
Description A disorder characterized by irregular and infrequent or difficult evacuation of the bowels. [CTCAE] Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections. | Difficult defecation. | Symptom characterized by the passage of stool once a week or less. [MeSH]
MedDRA Code 10010774
MeSH ID D003248
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Constipation | Constipation (excl faecal impaction) | Iatrogenic constipation | Obstipation | Constipation aggravated | Constipation (excl fecal impaction) | Stools absent | Constipation chronic | Opioid induced constipation | Slow transit constipation | Chronic idiopathic constipation | Absent bowel movement | Habitual constipation | Dyschezia | Colonic Inertia
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01866Propoxyphene napsylate--
BADD_D01867Propranolol0.002276%
BADD_D01868Propranolol hydrochloride--
BADD_D01872Protriptyline--
BADD_D01873Protriptyline hydrochloride--
BADD_D01874Prucalopride0.002239%
BADD_D01875Prussian blue--
BADD_D01886Pyrimethamine0.000482%
BADD_D01888Quetiapine--
BADD_D01889Quetiapine fumarate--
BADD_D01890Quinapril--
BADD_D01891Quinapril hydrochloride--
BADD_D01892Quinaprilat--
BADD_D01898Rabeprazole0.000521%
BADD_D01899Rabeprazole sodium--
BADD_D01906Raltegravir potassium--
BADD_D01907Raltitrexed--
BADD_D01909Ramipril--
BADD_D01910Ramiprilat--
BADD_D01912Ranibizumab--
BADD_D01913Ranitidine--
BADD_D01914Ranitidine hydrochloride--
BADD_D01915Ranolazine0.011522%
BADD_D01916Rasagiline mesylate--
BADD_D01917Rasburicase--
BADD_D01919Reboxetine--
BADD_D01922Regorafenib0.008753%
BADD_D01923Remifentanil hydrochloride--
BADD_D01924Repaglinide--
BADD_D01925Rescinnamine--
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